Phosphoglycerate mutase 1 that is essential for glycolysis may act as a novel metabolic target for predicating poor prognosis for patients with gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24718
Abstract: To identify a novel marker for gastric cancer, we examined the usefulness of phosphoglycerate mutase 1 (PGAM1) as a potential diagnostic marker using isobaric tags for relative and absolute quantitation (iTRAQ)‐based quantitative proteomics and evaluated… read more here.
Keywords: phosphoglycerate mutase; gastric cancer; mutase essential;
Structural analysis of EhPSP in complex with 3-phosphoglyceric acid from Entamoeba histolytica reveals a basis for its lack of phosphoglycerate mutase activity.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.153
Abstract: Entamoeba histolytica phosphoserine phosphatase (EhPSP), a regulatory enzyme in the serine biosynthetic pathway, is also a structural homolog of cofactor-dependent phosphoglycerate mutase (dPGM). However, despite sharing many of its catalytic residues with dPGM, EhPSP displays… read more here.
Keywords: ehpsp; ehpsp complex; phosphoglycerate mutase; entamoeba histolytica ... See more keywords
Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic potential
Sign Up to like & getrecommendations! Published in 2022 at "Parasite"
DOI: 10.1051/parasite/2022042
Abstract: Schistosomiasis is a debilitating parasitic disease caused by intravascular flatworms called schistosomes (blood flukes) that affects >200 million people worldwide. Proteomic analysis has revealed the surprising presence of classical glycolytic enzymes – typically cytosolic proteins… read more here.
Keywords: schistosoma mansoni; phosphoglycerate mutase; pgm;
Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging
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DOI: 10.1111/acel.13546
Abstract: Decline in ovarian reserve with aging is associated with reduced fertility and the development of metabolic abnormalities. Once mitochondrial homeostasis is imbalanced, it may lead to poor reproductive cell quality and aging. However, Phosphoglycerate translocase… read more here.
Keywords: pgam5; phosphoglycerate mutase; quality; family member ... See more keywords
Phosphoglycerate mutase 5 promotes necroptosis in trophoblast cells through activation of dynamin-related protein 1 in early-onset preeclampsia.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of reproductive immunology"
DOI: 10.1111/aji.13539
Abstract: OBJECTIVES Placentae from patients with preeclampsia have increased susceptibility tonecroptosis and phosphoglycerate mutase 5 (PGAM5) plays a role in many necrosis pathways.We determined whether PGAM5 promotes necroptosis of trophoblast cells and the underlying mechanisms in… read more here.
Keywords: promotes necroptosis; trophoblast cells; pgam5; phosphoglycerate mutase ... See more keywords
Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0250856
Abstract: Glycolytic metabolism is closely involved in physiological homeostasis and pathophysiological states. Among glycolytic enzymes, phosphoglycerate mutase (PGAM) has been reported to exert certain physiological role in vitro, whereas its impact on glucose metabolism in vivo… read more here.
Keywords: characterization genetically; phosphoglycerate mutase; genetically modified; mice ... See more keywords
Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007971
Abstract: The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection. However, glucose consumption increases the cellular demand for manganese sensitizing S. aureus to host-imposed manganese starvation. The current investigations were… read more here.
Keywords: variants phosphoglycerate; metal independent; infection; metal ... See more keywords
Virtual Screening, Molecular Dynamics and ADME-Tox Tools for Finding Potential Inhibitors of Phosphoglycerate Mutase 1 from Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026618666181029144653
Abstract: BACKGROUND Nowadays, malaria is still one of the most important and lethal diseases worldwide, causing 445,000 deaths in a year. Due to the actual treatment resistance, there is an emergency to find new drugs. OBJECTIVE… read more here.
Keywords: virtual screening; potential inhibitors; inhibitors phosphoglycerate; phosphoglycerate mutase ... See more keywords
Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1052363
Abstract: Phosphoglycerate mutase 2 (PGAM2) is a critical glycolytic enzyme that is highly expressed in skeletal muscle. In humans, naturally occurring mutations in Phosphoglycerate mutase 2 have been etiologically linked to glycogen storage disease X (GSDX).… read more here.
Keywords: mutase; sumoylation; differentiation; c2c12 cells ... See more keywords
High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113198
Abstract: Phosphoglycerate mutase (PGAM) is a glycolytic enzyme converting 3-phosphoglycerate to 2-phosphoglycerate, which in mammalian cells is expressed in two isoforms: brain (PGAM1) and muscle (PGAM2). Recently, it was shown that besides its enzymatic function, PGAM2… read more here.
Keywords: structure; pgam2; muscle; phosphoglycerate mutase ... See more keywords
[Research progress of phosphoglycerate mutase 5-mediated mitophagy and necroptosis].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.cn121430-20220428-00431
Abstract: Mitophagy is the selective degradation of damaged mitochondria, and it is of great significance to maintain the normal quantity and quality of mitochondria to ensure cell homeostasis and survival. Necroptosis is a type of programmed… read more here.
Keywords: necroptosis; phosphoglycerate mutase; mitophagy necroptosis; mediated mitophagy ... See more keywords