Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins.
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DOI: 10.1016/j.jmb.2019.02.019
Abstract: WIPI proteins are mammalian PROPPIN family members that bind to phosphoinositides and play prominent roles in autophagosome biogenesis. Two phosphoinositide-binding sites were previously described in yeast PROPPIN Hsv2 but remain to be determined in mammalian… read more here.
Keywords: conservation two; two phosphoinositide; phosphoinositide binding; binding sites ... See more keywords
A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum
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DOI: 10.1128/mbio.03239-21
Abstract: Malaria represents an enormous burden for a significant proportion of humanity and the lack of vaccines and problems with drug resistance to all antimalarials demonstrate the need to develop new therapeutics. Inhibitors of phosphoinositide metabolism… read more here.
Keywords: binding protein; parasite plasmodium; malaria parasite; plasmodium falciparum ... See more keywords