Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
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DOI: 10.1021/acsomega.2c02020
Abstract: The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P3) independent manner. To understand this new PDK1 regulatory mechanism, docking and… read more here.
Keywords: protein kinase; pdk1; kinase; dependent protein ... See more keywords
The 3-phosphoinositide–dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001483
Abstract: Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however, are only partially… read more here.
Keywords: kinase essential; phosphoinositide dependent; protein kinase; pfpkac ... See more keywords