Defective phosphoinositide metabolism in autism
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23797
Abstract: Phosphoinositides are essential components of lipid membranes and crucial regulators of many cellular functions, including signal transduction, vesicle trafficking, membrane receptor localization and activity, and determination of membrane identity. These functions depend on the dynamic… read more here.
Keywords: metabolism; autism; phosphoinositide metabolism; phosphoinositide kinases ... See more keywords
Dishevelled coordinates phosphoinositide kinases PI4KIIIα and PIP5KIγ for efficient PtdInsP2 synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259145
Abstract: Phosphatidylinositol(4,5)-bisphosphate (PtdInsP2) is an important modulator of many cellular processes and its abundance in the plasma membrane is closely regulated. We examined the hypothesis that the scaffolding protein Dishevelled can bind the lipid kinases PI4K… read more here.
Keywords: pi4kiii pip5ki; ptdinsp2; ptdinsp2 synthesis; phosphoinositide kinases ... See more keywords
TOCOTRIENOL-RICH FRACTION MODULATE THE PHOSPHOINOSITIDE 3-KINASES/AKT SIGNALING PATHWAY GENES AND PREVENT OXIDATIVE STRESS IN NICOTINE-INDUCED PRE-IMPLANTATION EMBRYOS
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2019.v11s5.t0055
Abstract: Objective: This study aimed to determine the effects of the tocotrienol-rich fraction (TRF) on the regulations of phosphoinositide 3-kinases (PI3K)/Aktpathways related genes in preimplantation embryos induced by nicotine (Nic).Methods: Twenty-four female BALB/c mice were divided… read more here.
Keywords: akt signaling; phosphoinositide kinases; signaling pathway; rich fraction ... See more keywords