The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
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DOI: 10.1172/jci.insight.152638
Abstract: Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently hydrolyzes… read more here.
Keywords: iia; phospholipase iia; microbiota; spla2 iia ... See more keywords