One-pot, four-component synthesis of spiroindoloquinazoline derivatives as phospholipase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.07.005
Abstract: Abstract An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile… read more here.
Keywords: four component; synthesis spiroindoloquinazoline; spiroindoloquinazoline derivatives; phospholipase inhibitors ... See more keywords
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00682
Abstract: Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human cancer progression as well as… read more here.
Keywords: phospholipase; phospholipase inhibitors; discovery phospholipase; pld ... See more keywords