CD19 Targeted Low-Dose Rituximab Is Effective in the Management of Refractory Phospholipase A2 Receptor Antibody-Associated Membranous Nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2016.08.019
Abstract: To the Editor: Varied dosing regimens of rituximab (RTX) have been successfully used in the management of primary membranous nephropathy (PMN). An ideal RTX dose and the long-term adverse effect of a larger cumulative dose… read more here.
Keywords: cd19; low dose; range; management ... See more keywords
Rituximab in Patients With Phospholipase A2 Receptor–Associated Membranous Nephropathy and Severe CKD
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DOI: 10.1016/j.ekir.2019.12.006
Abstract: Introduction Patients with phospholipase A2 receptor (PLA2R)–associated membranous nephropathy and stage 4 or 5 chronic kidney disease are at high risk of end-stage kidney disease. In recent years, rituximab (RTX) emerged as a safe and… read more here.
Keywords: associated membranous; patients phospholipase; treatment; membranous nephropathy ... See more keywords
Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.06.007
Abstract: M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing idiopathic membranous nephropathy (IMN), which is an autoimmune disease and one of… read more here.
Keywords: crystal structure; ctld7; structure ctld7; phospholipase receptor ... See more keywords
Current insights into functions of phospholipase A2 receptor in normal and cancer cells: More questions than answers.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.11.002
Abstract: Lipid signaling network was proposed as a potential target for cancer prevention and treatment. Several recent studies revealed that phospholipid metabolising enzyme, phospholipase A2 (PLA2), is a critical regulator of cancer accelerating pathologies and apoptosis… read more here.
Keywords: current insights; insights functions; phospholipase receptor; cancer ... See more keywords
Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1
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DOI: 10.1038/s41598-020-64863-y
Abstract: The Phospholipase A2 Receptor 1 (PLA2R1) was first identified for its ability to bind some secreted PLA2s (sPLA2s). It belongs to the C-type lectin superfamily and it binds different types of proteins. It is likely… read more here.
Keywords: conditional transgenic; transgenic mouse; phospholipase receptor; hpla2r1 ... See more keywords
Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2039705
Abstract: Abstract Background The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The… read more here.
Keywords: pla2r antibodies; anti pla2r; damage; pla2r ... See more keywords
MiR-130a-5p prevents angiotensin II-induced podocyte apoptosis by modulating M-type phospholipase A2 receptor
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1542901
Abstract: ABSTRACT Podocyte apoptosis is considered as the important element that promotes the development and progress of membranous nephropathy (MN). Unfortunately, the underlying mechanism of podocytes apoptosis in MN remains elusive. We compared the renal expressions… read more here.
Keywords: podocyte apoptosis; apoptosis; phospholipase receptor; type phospholipase ... See more keywords
Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis
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DOI: 10.1177/0961203319828521
Abstract: Background Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was… read more here.
Keywords: antibodies type; lupus nephritis; phospholipase receptor; lupus ... See more keywords
Treatment resistant M-type phospholipase A2 receptor associated membranous nephropathy responds to obinutuzumab: a report of two cases
Sign Up to like & getrecommendations! Published in 2022 at "BMC Nephrology"
DOI: 10.1186/s12882-022-02761-3
Abstract: Background Membranous Nephropathy (MN) is a common cause of nephrotic syndrome (NS) in adults. Recognition of MN as an antibody mediated autoimmune disease has enabled the introduction of anti-B-cell therapy. Rituximab, a type I anti-CD20… read more here.
Keywords: pla2r associated; phospholipase receptor; treatment; membranous nephropathy ... See more keywords
Anti-Phospholipase A2 Receptor Antibodies in Biopsy-Proven Idiopathic Membranous Nephropathy: A Report from the Pakistani Population.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2022.07.950
Abstract: This study aimed to determine the percentage of anti-phospholipase A2 receptor (PLA2R) autoantibody positivity in a cross-section of 74 Pakistani patients with biopsy-proven idiopathic membranous nephropathy. It was an observational study conducted from December 2018… read more here.
Keywords: idiopathic membranous; biopsy proven; phospholipase receptor; membranous nephropathy ... See more keywords
Hypercholesterolemia Correlates With Glomerular Phospholipase A2 Receptor Deposit and Serum Anti-Phospholipase A2 Receptor Antibody and Predicts Proteinuria Outcome in Idiopathic Membranous Nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.905930
Abstract: Background The anti-phospholipase A2 receptor (PLA2R) antibody is a non-invasive diagnostic tool and prognosis predictor of idiopathic membranous nephropathy (IMN). Baseline hypercholesterolemia independently predicts proteinuria outcomes in IMN patients. Thus, we investigated whether hyperlipidemia is… read more here.
Keywords: hypercholesterolemia; phospholipase receptor; deposit; receptor ... See more keywords