Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment
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DOI: 10.1111/andr.12796
Abstract: Oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm‐specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ… read more here.
Keywords: indicative optimal; zeta profiles; sperm; phospholipase zeta ... See more keywords
Phospholipase C zeta (PLCζ) and the clinical diagnosis of oocyte activation deficiency.
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DOI: 10.1530/rep-21-0458
Abstract: Oocyte activation deficiency (OAD) remains the predominant cause of total/low fertilization rate in assisted reproductive technology (ART). Phospholipase C zeta (PLCζ) is the dominant sperm-specific factor responsible for triggering oocyte activation in mammals. OAD has… read more here.
Keywords: activation; plc; oocyte activation; activation deficiency ... See more keywords