Biocompatible phospholipid‐based nanovesicular drug delivery system of ketoprofen: Systematic development, optimization, and preclinical evaluation
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DOI: 10.1002/bab.2328
Abstract: The present work involved development of phospholipid‐based permeation enhancing nanovesicles (PENVs) for topical delivery of ketoprofen. Screening of phospholipids and process parameters was performed. Central composite design was used for optimization of factors, that is,… read more here.
Keywords: evaluation; development; phospholipid based; drug ... See more keywords
Biocompatible phospholipid-based mixed micelles for posaconazole ocular delivery: Development, characterization, and in - vitro antifungal activity
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DOI: 10.1177/08853282221141962
Abstract: Current study intended to prepare and evaluate phospholipid-based, mixed micelles (MMs) to improve the ocular delivery of posaconazole (POS), a broad-spectrum antifungal drug. For this, MMs based on egg phosphatidylcholine (EPC), as the main component,… read more here.
Keywords: ocular delivery; antifungal activity; vitro antifungal; phospholipid based ... See more keywords
Molecular Modeling-Guided Design of Phospholipid-Based Prodrugs
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DOI: 10.3390/ijms20092210
Abstract: The lipidic prodrug approach is an emerging field for improving a number of biopharmaceutical and drug delivery aspects. Owing to their structure and nature, phospholipid (PL)-based prodrugs may join endogenous lipid processing pathways, and hence… read more here.
Keywords: based prodrugs; molecular modeling; drug; phospholipid based ... See more keywords
Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery
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DOI: 10.3390/ph15050515
Abstract: Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms. This work aimed to develop IMQ-loaded microemulsions… read more here.
Keywords: cutaneous imiquimod; phospholipid based; imq; microemulsions cutaneous ... See more keywords
Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations
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DOI: 10.3390/pharmaceutics11040186
Abstract: In ulcerative colitis (UC), the inflammation is localized in the colon, and one of the successful strategies for colon-targeting drug delivery is the prodrug approach. In this work, we present a novel phospholipid (PL)-based prodrug… read more here.
Keywords: based prodrugs; drug delivery; pla2; colon ... See more keywords
RETRACTED: Alhakamy et al. Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells. Pharmaceutics 2020, 12, 761
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DOI: 10.3390/pharmaceutics16020156
Abstract: The journal retracts the article, "Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells" [...]. read more here.
Keywords: phytosomes exhibit; based phytosomes; thymoquinone loaded; phospholipid based ... See more keywords