Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid–phospholipid complex
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1583755
Abstract: Abstract Objective: To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal… read more here.
Keywords: methodology; phospholipid complex; ursolic acid; bioavailability ... See more keywords
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2025.2519975
Abstract: Abstract Objective To prepare the Coreopsis tinctoria flavonoids phospholipid complex(CTF-PC) and evaluate its physical characterization and release profile. Significance Coreopsis Tinctoria flavonoids (CTF) have excellent antioxidant and liver-protective activity. However, CTF exhibits low solubility and… read more here.
Keywords: coreopsis tinctoria; release; tinctoria flavonoids; phospholipid complex ... See more keywords
A novel matrix dispersion based on phospholipid complex for improving oral bioavailability of baicalein: preparation, in vitro and in vivo evaluations
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1311968
Abstract: Abstract Phospholipid complex is one of the most successful approaches for enhancing oral bioavailability of poorly absorbed plant constituents. But the sticky property of phospholipids results in an unsatisfactory dissolution of drugs. In this study,… read more here.
Keywords: oral bioavailability; bapc; phospholipid complex; baicalein ... See more keywords
Optimized piperine–phospholipid complex with enhanced bioavailability and hepatoprotective activity
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1835956
Abstract: Abstract Piper species is one of the most widely consumed spices for culinary purposes. Piperine (PIP) present in Piper species has a wide range of therapeutic activity including hepatoprotection. However, the major biological limitation of… read more here.
Keywords: phospholipid complex; bioavailability; ppc; pip ... See more keywords
Chrysin–phospholipid complex-based solid dispersion for improved anti-aging and neuroprotective effects in mice
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2023.2165102
Abstract: Abstract The present study aimed to improve the neuroprotective effect of chrysin (CHR) by combining two formulation techniques, phospholipid (PL) complexation and solid dispersion (SD). CHR-phospholipid complex (CHR-PLC) was prepared through solvent evaporation. The molar… read more here.
Keywords: solid dispersion; plain chr; chr plc; phospholipid complex ... See more keywords
Solubilisation of quercetin in phospholipid complex improves its anti-hyperuricaemia activity in mice.
Sign Up to like & getrecommendations! Published in 2025 at "Natural product research"
DOI: 10.1080/14786419.2025.2478647
Abstract: Previous studies have confirmed that quercetin (Que) has a good therapeutic effect on lowering uric acid and hyperuricaemia. However, due to its poor water solubility, the bioavailability is low with limited application. This research aimed… read more here.
Keywords: hyperuricaemia; que; quercetin phospholipid; anti hyperuricaemia ... See more keywords
Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1
Sign Up to like & getrecommendations! Published in 2018 at "Poultry Science"
DOI: 10.3382/ps/pey155
Abstract: Abstract Duck hepatitis A virus type 1 (DHAV‐1) is one of the main pathogens of ducklings and causes a high mortality rate. Baicalin (BA) has potent antiviral effect, but the solubility is very poor. In… read more here.
Keywords: dhav; phospholipid complex; antiviral effect; virus type ... See more keywords