Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation
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DOI: 10.1002/cmdc.202000317
Abstract: Novel phospholipid (PL)‐cyclosporine conjugates were prepared and studied as potential prodrugs for inflammatory bowel disease (IBD). Our approach relies on phospholipase A2 (PLA2), which is overexpressed in the inflamed intestinal tissues, as the prodrug activator… read more here.
Keywords: phospholipid cyclosporine; bowel disease; inflammatory bowel; disease ibd ... See more keywords