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   Articles with "phospholipid scramblase" as a keyword



Phospholipid scramblase 1: a frontline defense against viral infections

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recommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2025.1573373

Abstract: Phospholipid scramblase 1 (PLSCR1) is the most studied member of the phospholipid scramblase protein family. Its main function is to catalyze calcium (Ca2+)-dependent, ATP-independent, bidirectional and non-specific translocation of phospholipids between inner and outer leaflets… read more here.

Keywords: frontline defense; viral infections; virus; defense viral ... See more keywords

STAT3 Cooperates With Phospholipid Scramblase 2 to Suppress Type I Interferon Response

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recommendations! Published in 2018 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2018.01886

Abstract: Type I interferon (IFN-I) is a pluripotent cytokine that modulates innate and adaptive immunity. We have previously shown that STAT3 suppresses IFN-I response in a manner dependent on its N-terminal domain (NTD), but independent of… read more here.

Keywords: type interferon; response; stat3; plscr2 ... See more keywords

Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179787

Abstract: Phospholipid scramblase 4 (PLSCR4) is a member of a conserved enzyme family with high relevance for the remodeling of phospholipid distribution in the plasma membrane and the regulation of cellular signaling. While PLSCR1 and -3… read more here.

Keywords: pip3; phospholipid scramblase; adipose tissue; scramblase plscr4 ... See more keywords

TMEM41B, a novel ER phospholipid scramblase mediating systemic lipid metabolism

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recommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.3724/abbs.2022168

Abstract: The phospholipid molecules forming the phospholipid bilayer membrane have difficulties to complete spontaneous trans-bilayer shuttling due to the physicochemical properties and biological functions of the membrane bilayer [1]. However, this transbilayer phospholipid transport is essential… read more here.

Keywords: phospholipid scramblase; novel phospholipid; systemic lipid; mediating systemic ... See more keywords