Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.04.016
Abstract: ABSTRACT Considerable effort has been made to develop nanocarriers for controlled drug delivery over the last decade, while it remains unclear how the strength of adverse drug effect will be altered when a drug is… read more here.
Keywords: induced phospholipidosis; drug induced; drug; effect ... See more keywords
A multiplexed UPLC‐MS/MS assay for the simultaneous measurement of urinary safety biomarkers of drug‐induced kidney injury and phospholipidosis
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.01.012
Abstract: ABSTRACT Drug‐induced kidney injury (DIKI) is a major concern in drug risk assessment given its clinical importance and the absence of a sensitive/specific method of diagnosis. Pharmaceutical regulatory agencies have qualified and issued letters of… read more here.
Keywords: kidney injury; drug induced; drug; phospholipidosis ... See more keywords
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone
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DOI: 10.1177/0192623318809000
Abstract: Cationic amphiphilic drugs (CADs) can induce phospholipidosis (PLD) in organs/tissues. Several ophthalmic pharmaceuticals containing CADs are marketed and used in children. To investigate the effect of PLD on the developing cornea, chloroquine and amiodarone, which… read more here.
Keywords: young adult; amiodarone; chloroquine amiodarone; adult rabbits ... See more keywords
Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2016-0003
Abstract: Several cationic-amphiphilic drugs such as chloroquine and amiodarone are known to induce phospholipidosis in the cornea by systemic administration. However, the characteristics of ophthalmological and pathological changes when phospholipidosis-inducing drugs are topically applied have not… read more here.
Keywords: microscopy; chloroquine amiodarone; phospholipidosis; characteristics corneal ... See more keywords