Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C-C Bond.
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DOI: 10.1021/jacs.2c06546
Abstract: Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced by the soil-dwelling bacterium Saccharothrix sp. ST-888, exhibits herbicidal activity. In this study, we propose a… read more here.
Keywords: thiamine diphosphate; dependent enzymes; phosphonate phosphonothrixin; complete biosynthetic ... See more keywords