Facile Modifications at the C4 Position of Pyrimidine Nucleosides via In Situ Amide Activation with 1H‐Benzotriazol‐1‐yloxy‐tris(dimethyl‐amino)phosphonium Hexafluorophosphate
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DOI: 10.1002/cpnc.73
Abstract: Two approaches for C4 modifications of silyl‐protected thymidine, 2′‐deoxyuridine, and 3′‐azido‐2′,3′‐dideoxythymidine (AZT) are described. In both, nucleoside amide activation with 1H‐benzotriazol‐1‐yloxy‐tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and DBU yields O4‐(benzotriazol‐1‐yl) derivatives. These in situ–formed intermediates are reacted with… read more here.
Keywords: phosphonium hexafluorophosphate; yloxy tris; benzotriazol; activation benzotriazol ... See more keywords