Application of Phosphoramidate ProTide Technology for the Synthesis of 5’‐mRNA Cap Analogs Modified on the Exocyclic Amine Group
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DOI: 10.1002/cmdc.202200490
Abstract: Aryloxy triester phosphoramidate methodology, commonly known as ProTide technology, is one of the most widely used prodrug approaches applied to therapeutic nucleosides. This approach has been used extensively by the pharmaceutical industry and researchers in… read more here.
Keywords: cap; synthesis; protide technology; mrna cap ... See more keywords
A Ribonucleotide ↔ Phosphoramidate Reaction Network Optimized by Computer-Aided Design
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DOI: 10.1021/jacs.2c05861
Abstract: A growing number of out-of-equilibrium systems have been created and investigated in chemical laboratories over the past decade. One way to achieve this is to create a reaction cycle, in which the forward reaction is… read more here.
Keywords: reaction; microscopy; reaction network; design ... See more keywords
Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1922400117
Abstract: Significance Life on Earth depends on polymerases. These enzymes copy genetic information to produce the DNA and RNA strands at the core of the central dogma. Polymerases act by forming phosphodiester linkages to produce polynucleotide… read more here.
Keywords: dna; dna polymerase; activity; polymerase ... See more keywords
Novel Lipid-Oligonucleotide Conjugates Containing Long-Chain Sulfonyl Phosphoramidate Groups: Synthesis and Biological Properties
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DOI: 10.3390/app11031174
Abstract: New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3′ or 5′-end were synthesized and characterized. Low cytotoxicity of the conjugates and their ability… read more here.
Keywords: novel lipid; sulfonyl phosphoramidate; oligonucleotide conjugates; phosphoramidate ... See more keywords