A convenient solid phase approach to obtain lipophilic 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides
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DOI: 10.1080/15257770.2017.1421765
Abstract: ABSTRACT This paper explores the potential of a modified phosphotriester approach to the synthesis of 5′-phosphoramidate derivatives of DNA and RNA oligonucleotides. The modification of 5′-deprotected support-bound oligonucleotides is done in two steps: i) conversion… read more here.
Keywords: rna oligonucleotides; derivatives dna; phosphoramidate derivatives; solid phase ... See more keywords