Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.
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DOI: 10.1038/s41422-022-00651-9
Abstract: The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discovery and development of a class of potent activators… read more here.
Keywords: discovery small; small molecule; phosphoribosyltransferase nampt; activity ... See more keywords
Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibitsin vitroandin vivoefficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia
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DOI: 10.1158/1538-7445.am2017-1942
Abstract: Cancer cells are highly dependent on nicotinamide phosphoribosyltransferase (NAMPT) for the biosynthesis of nicotinamide adenine dinucleotide (NAD). Besides its role in energy metabolism, NAMPT influences the activity of NAD-dependent enzymes, including poly (ADP-ribose) polymerase-1 (PARP-1)… read more here.
Keywords: cell; phosphoribosyltransferase nampt; nampt inhibitor; acute lymphoblastic ... See more keywords
Abstract 5477: Targeting nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 in Ewing sarcoma
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DOI: 10.1158/1538-7445.am2018-5477
Abstract: EWS is an aggressive malignancy affecting adolescents and young adults, for which novel therapies are critically needed. Recent insights have revealed that NAMPT is a potential therapeutic target, mediating the rate limiting step of the… read more here.
Keywords: phosphoribosyltransferase nampt; cell lines; targeting nicotinamide; biology ... See more keywords
Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
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DOI: 10.3390/pharmaceutics15051472
Abstract: The nicotinamide phosphoribosyltransferase (NAMPT) is considered a very promising therapeutic target because it is overexpressed in pancreatic cancer. Although many inhibitors have been prepared and tested, clinical trials have shown that NAMPT inhibition may result… read more here.
Keywords: pancreatic cancer; nicotinamide phosphoribosyltransferase; phosphoribosyltransferase nampt; iminosugar based ... See more keywords