Corroboration of Zn( ii )–Mg( ii )-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme
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DOI: 10.1039/c8ra05083j
Abstract: The TW17 ribozyme, a catalytic RNA selected from a pool of artificial RNA, is specific for the Zn2+-dependent hydrolysis of a phosphorothiolate thiolester bond. Here, we describe the organic synthesis of both guanosine α-thio-monophosphate and… read more here.
Keywords: ribozyme catalysis; ribozyme; catalysis; phosphorothiolate ... See more keywords