Novel Liver-targeted conjugates of Glycogen Phosphorylase Inhibitor PSN-357 for the Treatment of Diabetes: Design, Synthesis, Pharmacokinetic and Pharmacological Evaluations
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DOI: 10.1038/srep42251
Abstract: PSN-357, an effective glycogen phosphorylase (GP) inhibitor for the treatment for type 2 diabetics, is hampered in its clinical use by the poor selectivity between the GP isoforms in liver and in skeletal muscle. In… read more here.
Keywords: glycogen phosphorylase; phosphorylase inhibitor; liver targeted; psn 357 ... See more keywords