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Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131648
Abstract: Abstract Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote angiogenesis,…
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Keywords:
thymidine phosphorylase;
virtual screening;
thymidine;
multilevel virtual ... See more keywords
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Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00494
Abstract: A number of studies have shown high levels of thymidine phosphorylase (TP) expression in glioblastoma (GBM), with trace or undetectable TP levels in normal developed brain tissue. TP catalyzes the reversible phosphorolysis of thymidine to…
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Keywords:
thymidine phosphorylase;
thymidine;
inhibitors glioblastoma;
evaluation thymidine ... See more keywords
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Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220420133644
Abstract: AIMS This study aimed to recommend a novel way for the preparation of carbohydrates containing triazole derivatives. BACKGROUND Triazoles containing derivatives have numerous biological activities. Ball milling is a fast, modest, green process with massive…
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Keywords:
glycogen phosphorylase;
triazole;
phosphorylase inhibitors;
reaction ... See more keywords
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Published in 2017 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-1602-79
Abstract: This review paper covers recent advances in the synthetic strategies for novel TPase inhibitors and their potential medicinal applications over the last few decades. A brief introduction covering the structural aspects of TPase inhibitors is…
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Keywords:
thymidine phosphorylase;
advances thymidine;
medicinal applications;
inhibitors syntheses ... See more keywords