2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1
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DOI: 10.1007/s00204-018-2289-6
Abstract: The Japanese Ministry of Health, Labour, and Welfare recently reported an outbreak of bladder cancer among workers who handled aromatic amines in Japan. 2,4-dimethylaniline (2,4-DMA) is one of the chemicals that workers are considered to… read more here.
Keywords: reactive oxygen; histone h2ax; oxygen species; h2ax ... See more keywords
Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain
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DOI: 10.1038/srep41221
Abstract: Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational modifications in histones are pivotal in regulating transcription. Here, we report that… read more here.
Keywords: tissue injury; phosphorylated histone; serine; development ... See more keywords
The Highest Density of Phosphorylated Histone H1 Appeared in Prophase and Prometaphase in Parallel with Reduced H3K9me3, and HDAC1 Depletion Increased H1.2/H1.3 and H1.4 Serine 38 Phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12060798
Abstract: Background: Variants of linker histone H1 are tissue-specific and are responsible for chromatin compaction accompanying cell differentiation, mitotic chromosome condensation, and apoptosis. Heterochromatinization, as the main feature of these processes, is also associated with pronounced… read more here.
Keywords: density phosphorylated; prophase prometaphase; histone; hdac1 depletion ... See more keywords