Multiple phosphorylated protein selective analysis via fluorous derivatization and liquid chromatography-electrospray ionization-mass spectrometry analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114247
Abstract: Post-translational modification of proteins is involved in protein function and higher-order structure. Among such modification, phosphorylation is an important intracellular signal transduction pathway. Many studies on phosphorylated protein analysis using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS)… read more here.
Keywords: analysis; phosphorylated peptides; chromatography electrospray; liquid chromatography ... See more keywords
Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104013
Abstract: Summary Phosphopeptides presented by major histocompatibility complex (MHC) class I have been regarded as a pivotal type of cancer neoantigens that are recognized by T cells. The structural basis of single-phosphorylated peptide presentation has been… read more here.
Keywords: mhc class; class molecules; presentation; phosphorylated peptides ... See more keywords
Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-00959-w
Abstract: The deposition of neurotoxic amyloid-β (Aβ) peptides in extracellular plaques in the brain parenchyma is one of the most prominent neuropathological features of Alzheimer’s disease (AD), and considered to be closely related to the pathogenesis… read more here.
Keywords: mouse models; phosphorylated peptides; peptides human; deposition ... See more keywords