Synaptic phosphorylated &agr;-synuclein in dementia with Lewy bodies
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DOI: 10.1093/brain/awx275
Abstract: Dementia with Lewy bodies is characterized by the accumulation of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated α-synuclein phosphorylated at Ser129. Although phosphorylated α-synuclein is believed… read more here.
Keywords: lewy bodies; dementia lewy; phosphorylated synuclein;
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-223294
Abstract: BACKGROUND Pathological changes in the brain can affect the gastrointestinal tract, whereas there is less evidence regarding the brain-gut axis. OBJECTIVE To identify whether cerebral endogenous phosphorylated α-synuclein induces gastrointestinal dysfunction via the brain-gut axis,… read more here.
Keywords: proximal colon; preformed fibrils; phosphorylated synuclein; brain ... See more keywords
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.
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DOI: 10.3233/jpd-223421
Abstract: BACKGROUND The role of peripheral phosphorylated-α-Synuclein (p-α-syn) deposition on nerve degeneration in synucleinopathies is still unknown. OBJECTIVE To assess the cutaneous neural distribution of p-α-Syn deposits and its correlation with clinical data and with morphology… read more here.
Keywords: phosphorylated synuclein; sensory autonomic; motor; syn ... See more keywords