Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2022.4485
Abstract: This cross-sectional study of 2 observational cohorts investigates if phosphorylated tau biomarkers are more associated with the presence of cerebral β-amyloidosis or tau neurofibrillary tangle aggregation. read more here.
Keywords: emission tomography; phosphorylated tau; positron emission;
Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2023.0199
Abstract: This cross-sectional study investigates associations of chronic kidney disease with plasma ratios of phosphorylated tau 217 and 181 to the corresponding unphosphorylated peptides in Alzheimer disease. read more here.
Keywords: associations kidney; disease; alzheimer disease; kidney dysfunction ... See more keywords
Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00919
Abstract: The accumulation and aggregation of the microtubule-associated protein tau (tau) into intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative tauopathies, including Alzheimer's disease (AD), frontotemporal dementia, Pick's disease, and progressive supranuclear… read more here.
Keywords: tau; tau accumulation; accumulation; analogs rhodacyanine ... See more keywords
Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra11637c
Abstract: We present the immunoassay of tau proteins (total tau and phosphorylated tau) in human sera using surface plasmon resonance (SPR) fiber sensors. This assay aimed at harvesting the advantages of using both SPR fiber sensors… read more here.
Keywords: immunoassay tau; fiber sensors; tau proteins; phosphorylated tau ... See more keywords
Possible neuroprotective effects of amide alkaloids from Bassia indica and Agathophora alopecuroides: in vitro and in silico investigations
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02275c
Abstract: In Alzheimer's disease (AD), the accumulation of amyloid-β plaques, overactivity of MAO-B, and phosphorylated tau protein in the central nervous system result in neuroinflammation and cognitive impairments. Therefore, the multi-targeting of these therapeutic targets has… read more here.
Keywords: amide alkaloids; indica; neuroprotective effects; tau protein ... See more keywords
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004425
Abstract: ABSTRACT The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18F-THK5351 is a first-generation PET tau tracer that also binds… read more here.
Keywords: stereotactic surface; 18f thk5351; surface projection; dimensional stereotactic ... See more keywords
Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.08.491088
Abstract: Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation. Recent findings of elevated levels… read more here.
Keywords: specific binding; aggregation; hsp27; ptau ... See more keywords
On the design of early-phase Alzheimer's disease clinical trials with cerebrospinal fluid tau outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical trials"
DOI: 10.1177/17407745211034497
Abstract: BACKGROUND/AIMS The focus of Alzheimer's disease studies has shifted to earlier disease stages, including mild cognitive impairment. Biomarker inclusion criteria are often incorporated into mild cognitive impairment clinical trials to identify individuals with "prodromal Alzheimer's… read more here.
Keywords: alzheimer disease; phosphorylated tau; disease; power ... See more keywords
Plasma Phosphorylated Tau at Threonine 181 and Neuropsychiatric Symptoms in Preclinical and Prodromal Alzheimer Disease
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DOI: 10.1212/wnl.0000000000201517
Abstract: Background and Objectives Plasma phosphorylated tau at threonine 181 (p-tau181), a well-validated marker of Alzheimer disease (AD) pathologic change, could be a more efficient way to diagnose AD than invasive or expensive biomarkers requiring CSF… read more here.
Keywords: disease; alzheimer disease; mbi; alzheimer ... See more keywords
Clinical Experience with Cerebrospinal Fluid Aβ42, Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-180548
Abstract: Background: Elevated total tau (tTau), 181-phosphorylated phosphorylated tau (pTau), and low amyloid-β42 (Aβ42) in cerebrospinal fluid (CSF) represent a diagnostic biomarker for Alzheimer’s disease (AD). Objective: The goal was to determine the overall accuracy of… read more here.
Keywords: phosphorylated tau; csf; sensitivity; specificity ... See more keywords
Phosphorylated Tau 181 Serum Levels Predict Alzheimer’s Disease in the Preclinical Stage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.900773
Abstract: Background There is an urgent need for cost-effective, easy-to-measure biomarkers to identify subjects who will develop Alzheimer’s disease (AD), especially at the pre-symptomatic stage. This stage can be determined in autosomal dominant AD (ADAD) which… read more here.
Keywords: serum; alzheimer disease; serum levels; stage ... See more keywords