Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14505
Abstract: Ack1 is a proto‐oncogenic tyrosine kinase with homology to the tumour suppressor Mig6, an inhibitor of the epidermal growth factor receptor (EGFR). The residues critical for binding of Mig6 to EGFR are conserved within the… read more here.
Keywords: kinase; mig6; activity; homology ... See more keywords
MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12102
Abstract: Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors.… read more here.
Keywords: erk; mek inhibitors; akt activation; activation ... See more keywords
Mitotic phosphorylation of CCCTC‐binding factor (CTCF) reduces its DNA binding activity
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DOI: 10.1002/2211-5463.12189
Abstract: During mitosis, higher order chromatin structures are disrupted and chromosomes are condensed to achieve accurate chromosome segregation. CCCTC‐binding factor (CTCF) is a highly conserved and ubiquitously expressed C2H2‐type zinc finger protein which is considered to… read more here.
Keywords: mitosis; ctcf; dna binding; binding activity ... See more keywords
TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts
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DOI: 10.1002/2211-5463.12195
Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.
Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords
SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
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DOI: 10.1002/2211-5463.12895
Abstract: Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular… read more here.
Keywords: sirt1; ampk ser485; senescence; ampk ... See more keywords
Targeted Delivery of PD‐L1‐Derived Phosphorylation‐Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment
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DOI: 10.1002/adhm.202200955
Abstract: Osteosarcoma is a rare malignant bone‐originating tumor that usually occurs in young people. Programmed cell death 1 ligand 1 (PD‐L1), an immune checkpoint protein, is highly expressed in osteosarcoma tissues. Several recent studies have indicated… read more here.
Keywords: derived phosphorylation; npm localized; phosphorylation mimicking; phosphorylation ... See more keywords
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors
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DOI: 10.1002/advs.202200717
Abstract: Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tumor cells to acquire chemoresistance‐conferring mutations… read more here.
Keywords: crispr mediated; functional phosphoproteomics; phosphorylation; chemoresistance ... See more keywords
Deafness‐Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment
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DOI: 10.1002/advs.202205993
Abstract: The ankle‐link complex (ALC) consists of USH2A, WHRN, PDZD7, and ADGRV1 and plays an important role in hair cell development. At present, its architectural organization and signaling role remain unclear. By establishing Adgrv1 Y6236fsX1 mutant… read more here.
Keywords: deafness associated; alc; stability; mutation ... See more keywords
Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and Tumorigenesis.
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DOI: 10.1002/advs.202206826
Abstract: The amino acid-stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation and function, but little is known about the effects of growth factors on… read more here.
Keywords: flcn phosphorylation; mediated mtorc1; mtorc1 activation; phosphorylation ... See more keywords
Choline ameliorates ethanol induced alterations in tyrosine phosphorylation and distribution in detergent-resistant membrane microdomains of L1 cell adhesion molecule in vivo.
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DOI: 10.1002/bdr2.1657
Abstract: BACKGROUND Exposure to ethanol during pregnancy is the cause of fetal alcohol spectrum disorder. The function of L1 cell adhesion molecule (L1), critical for proper brain development, is dependent on detergent-resistant membrane microdomains (DRM). Ethanol… read more here.
Keywords: choline; cell adhesion; adhesion molecule; ethanol induced ... See more keywords
Kinetics of diffusion-influenced multisite phosphorylation with enzyme reactivation.
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DOI: 10.1002/bip.23533
Abstract: The simplest way to account for the influence of diffusion on the kinetics of multisite phosphorylation is to modify the rate constants in the conventional rate equations of chemical kinetics. We have previously shown that… read more here.
Keywords: multisite phosphorylation; diffusion; rate; enzyme reactivation ... See more keywords