Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b00071
Abstract: Large-scale phosphoproteomics with coverage of over 10,000 sites of phosphorylation have now been routinely achieved with advanced mass spectrometry (MS)-based workflows. However, accurate targeted MS-based quantification of phosphorylation dynamics, an important direction for gaining quantitative… read more here.
Keywords: egfr mapk; phosphorylation dynamics; mapk pathway; quantification phosphorylation ... See more keywords
Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development
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DOI: 10.1038/s41598-017-15936-y
Abstract: The earliest stages of animal development are largely controlled by changes in protein phosphorylation mediated by signaling pathways and cyclin-dependent kinases. In order to decipher these complex networks and to discover new aspects of regulation… read more here.
Keywords: regulated proteome; phosphorylation dynamics; dominate regulated; dynamics dominate ... See more keywords
qPhos: a database of protein phosphorylation dynamics in humans
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1052
Abstract: Abstract Temporal and spatial protein phosphorylation dynamically orchestrates a broad spectrum of biological processes and plays various physiological and pathological roles in diseases and cancers. Recent advancements in high-throughput proteomics techniques greatly promoted the profiling… read more here.
Keywords: protein phosphorylation; phosphorylation dynamics; phosphorylation; qphos database ... See more keywords