Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.02.001
Abstract: Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs), the… read more here.
Keywords: response; vascular tone; nitric oxide; differential phosphorylation ... See more keywords
The effects of fluid shear stress and O2 concentration on the phosphorylation of eNOS at Ser635 in endothelial cells
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DOI: 10.1016/j.synres.2019.100046
Abstract: Abstract Under hypoxic conditions, NO plays an important role in regulating O2 delivery by controlling local blood vessel relaxation. NO is primarily produced by endothelial NO synthase (eNOS), which is reportedly phosphorylated at Ser635 and… read more here.
Keywords: fluid shear; stress concentration; stress; phosphorylation enos ... See more keywords
Inflammation of the Human Dental Pulp Induces Phosphorylation of eNOS at Thr495 in Blood Vessels
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071586
Abstract: The activity of endothelial nitric oxide synthase (eNOS) in endothelial cells increased with the phosphorylation of the enzyme at Ser1177 and decreased at Thr495. The regulation of the phosphorylation sites of eNOS at Ser1177 and… read more here.
Keywords: thr495; blood; blood vessels; pulp ... See more keywords