ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.
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DOI: 10.1016/j.devcel.2019.10.023
Abstract: Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate ERK1/2 activity in the heart, and inhibition of the ERK1/2 kinase activity ameliorates pathology,… read more here.
Keywords: positioning; phosphorylation fhod; activity; nuclear positioning ... See more keywords