S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions.
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DOI: 10.1038/s41467-022-28910-8
Abstract: Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains… read more here.
Keywords: s6k1 mediated; mediated phosphorylation; pdk1; phosphorylation pdk1 ... See more keywords