Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.052
Abstract: Mammalian Transducin-like enhancer of split (TLE) confer global repression of numerous target genes in conjunction with a myriad of DNA-binding repressors. These factors have a major role in the regulation of multiple signal transduction pathways.… read more here.
Keywords: tle3; differential functions; tle1 tle3; phosphorylation site ... See more keywords
MusiteDeep: a deep‐learning framework for general and kinase‐specific phosphorylation site prediction
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx496
Abstract: Motivation: Computational methods for phosphorylation site prediction play important roles in protein function studies and experimental design. Most existing methods are based on feature extraction, which may result in incomplete or biased features. Deep learning… read more here.
Keywords: deep learning; phosphorylation site; site prediction; phosphorylation ... See more keywords
A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac003
Abstract: Dear Editor, The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel emerging coronavirus that has spread worldwide since breaking out in late 2019 and has led to hundreds of millions of infections and… read more here.
Keywords: novel phosphorylation; phosphorylation site; host; phosphorylation ... See more keywords
Mutation of MtrA at the Predicted Phosphorylation Site Abrogates Its Role as a Global Regulator in Streptomyces venezuelae
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02131-21
Abstract: Although phosphorylation has been shown to be essential for the activation of many response regulator proteins of two-component systems, the role of the phosphorylation site in the function of the global regulator MtrA in the… read more here.
Keywords: mtra; site; phosphorylation; global regulator ... See more keywords
An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-15-1462
Abstract: The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory serine 472 phosphorylation site. Whereas the function of full-length Akt3… read more here.
Keywords: akt3 s472; akt3; 472 phosphorylation; phosphorylation site ... See more keywords
TransPhos: A Deep-Learning Model for General Phosphorylation Site Prediction Based on Transformer-Encoder Architecture
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084263
Abstract: Protein phosphorylation is one of the most critical post-translational modifications of proteins in eukaryotes, which is essential for a variety of biological processes. Plenty of attempts have been made to improve the performance of computational… read more here.
Keywords: phosphorylation; deep learning; phosphorylation site; site prediction ... See more keywords
The Solvation of the E. coli CheY Phosphorylation Site Mapped by XFMS
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112771
Abstract: The Escherichia coli CheY protein belongs to a large bacterial response regulator superfamily. X-ray hydroxy radical foot-printing with mass spectroscopy (XFMS) has shown that allosteric activation of CheY by its motor target triggers a concerted… read more here.
Keywords: chey; solvation; site; coli chey ... See more keywords