TLR4 phosphorylation at tyrosine 672 activates the ERK/c-FOS signaling module for LPS-induced cytokine responses in macrophages.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250056
Abstract: Toll-like receptors (TLRs) engage numerous adaptor proteins and signaling molecules, enabling a complex series of post-translational modifications (PTMs) to mount inflammatory responses. TLRs themselves are post-translationally modified following ligand-induced activation, with this being required to… read more here.
Keywords: phosphorylation tyrosine; inflammatory responses; tyrosine 672; tlr4 phosphorylation ... See more keywords
Umpolung Phosphorylation of Tyrosine via 1,2-Phospha-Brook Rearrangement.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c03223
Abstract: Phosphorylated tyrosine is a fundamental building block of bioactive peptides and proteins. However, the chemoselective phosphorylation of tyrosine over other nucleophilic amino acid residues in unprotected peptides remains a significant challenge. Here we report an… read more here.
Keywords: brook rearrangement; phospha brook; phosphorylation tyrosine; tyrosine ... See more keywords
Phosphorylation of Tyrosine and Tyr-Thr-Lys Tripeptide with Cyclohexylmethyl- and (Deuteromethyl)phosphonochloridates
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DOI: 10.1134/s1070363220040106
Abstract: Abstract Methods for phosphorylation of tyrosine and Tyr-Thr-Lys tripeptide with cyclohexylmethyl(deuteromethyl)phosphonochloridates have been developed. These products can be used as reference compounds in the analysis of blood plasma of patients presumably exposed to cyclohexylmethylphosphonofluoridate (cyclosarin)… read more here.
Keywords: tyrosine tyr; lys tripeptide; thr lys; phosphorylation tyrosine ... See more keywords
Corrigendum: RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion
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DOI: 10.3389/fonc.2021.729192
Abstract: [This corrects the article DOI: 10.3389/fonc.2021.665273.]. read more here.
Keywords: phosphorylation tyrosine; abl promotes; corrigendum runx2; runx2 phosphorylation ... See more keywords