Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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DOI: 10.1016/j.cell.2019.09.008
Abstract: Tyrosine phosphorylation regulates multi-layered signaling networks with broad implications in (patho)physiology, but high-throughput methods for functional annotation of phosphotyrosine sites are lacking. To decipher phosphotyrosine signaling directly in tissue samples, we developed a mass-spectrometry-based interaction… read more here.
Keywords: phosphotyrosine; signaling networks; tissue; phosphotyrosine sites ... See more keywords