Esterase-Activated, pH-Responsive, and Genetically Targetable Nano-Prodrug for Cancer Cell Photo-Ablation.
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DOI: 10.1002/smll.202207535
Abstract: Activatable prodrugs have drawn considerable attention for cancer cell ablation owing to their high specificity in drug delivery systems. However, phototheranostic prodrugs with dual organelle-targeting and synergistic effects are still rare due to low intelligence… read more here.
Keywords: nano prodrug; ablation; genetically targetable; esterase activated ... See more keywords
Selective photo-ablation of glioma cells using an enzyme activatable photosensitizer.
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DOI: 10.1039/d0cc05707j
Abstract: An activatable photosensitizer based on methylene blue was developed and validated for its efficacy in the selective killing of γ-glutamyl transpeptidase expressing cells. The 1O2 deactivation via bond breakage, rapid in situ enzymatic photosensitivity conversion,… read more here.
Keywords: ablation glioma; photo ablation; glioma cells; selective photo ... See more keywords