Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.03.024
Abstract: Abstract We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry and mass… read more here.
Keywords: minimally interfering; photo; synthesis electronically; tuned minimally ... See more keywords
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
Sign Up to like & getrecommendations! Published in 2017 at "Proteome Science"
DOI: 10.1186/s12953-017-0123-3
Abstract: Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that are crucial for biomedical research and drug discovery. Various techniques have been used to study specific proteins, including affinity chromatography, activity-based probes, affinity-based… read more here.
Keywords: protein; protein interactions; affinity; protein protein ... See more keywords