Why develop photoactivated chemotherapy?
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c8dt01585f
Abstract: Photoactivated chemotherapy is an approach where a biologically active compound is protected against interaction with the cell environment by a light-cleavable protecting group, and unprotected by light irradiation. As such, PACT represents a major scientific… read more here.
Keywords: photoactivated chemotherapy; pact; develop photoactivated; compound ... See more keywords
A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05998a
Abstract: A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells. read more here.
Keywords: cisplatin resistant; photodynamic therapy; photoactivated chemotherapy; therapy ... See more keywords
A Lock‐and‐Kill Anticancer Photoactivated Chemotherapy Agent †
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13738
Abstract: Photosubstitutionally active ruthenium complexes show high potential as prodrugs for the photoactivated chemotherapy (PACT) treatment of tumors. One of the problems in PACT is that the localization of the ruthenium compound is hard to trace.… read more here.
Keywords: lock kill; light irradiation; ruthenium; photoactivated chemotherapy ... See more keywords