UVA-induced photoaging inhibits autophagic degradation by impairing lysosomal function in dermal fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.103
Abstract: Autophagy has been associated with a variety of diseases especially aging. Human dermal fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced glycation end products (AGEs) in lysosomes, which plays prominent roles in… read more here.
Keywords: degradation; uva induced; induced photoaging; photoaged fibroblasts ... See more keywords
Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.02.009
Abstract: BACKGROUND The deposition of advanced glycation end products (AGEs) is accelerated in photoaged skin, but the underlying mechanisms remain elusive. Intracellular degradation has been recently considered to play an important role in AGEs removal. Although… read more here.
Keywords: non photoaged; degradation; age; photoaged fibroblasts ... See more keywords