Cas9 deactivation with photocleavable guide RNAs.
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DOI: 10.1016/j.molcel.2021.02.007
Abstract: Precise control of CRISPR-Cas9 would improve its safety and applicability. Controlled CRISPR inhibition is a promising approach but is complicated by separate inhibitor delivery, incomplete deactivation, and slow kinetics. To overcome these obstacles, we engineered… read more here.
Keywords: guide rnas; deactivation; cas9 deactivation; photocleavable guide ... See more keywords