Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid‐Membrane‐Incorporated Porphyrin Derivatives
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DOI: 10.1002/cmdc.202200070
Abstract: In this study we prepared aqueous solutions of lipid‐membrane incorporated tetraarylporphyrins and tetrapyridylporphyrin (LMIPors) by the injection method using dimethyl sulfoxide. The porphyrins with proton‐donor groups at the meso position afforded stable aqueous solutions of… read more here.
Keywords: photodynamic activity; lipid membrane; porphyrin; membrane incorporated ... See more keywords
On the origin of photodynamic activity of hypericin and its iodine‐containing derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27002
Abstract: The main photophysical properties, useful for establishing whether hypericin in anionic form and some of its derivatives containing heavy atoms such as iodine, can be proposed for their use in photodynamic therapy, were determined using… read more here.
Keywords: origin photodynamic; hypericin; hypericin iodine; photodynamic activity ... See more keywords
Self-assembling nanostructures of water-soluble fullerene[60]–chlorin e6 dyads: Synthesis, photophysical properties, and photodynamic activity
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108411
Abstract: Abstract The synthesis of water-soluble dyads PFD-Chl(1), PFD-Chl(Zn) and PFD-Chl(2) based on a polyanionic fullerene[60] derivative PFD covalently linked to chlorin e6 was described. Photophysical properties, generation of superoxide and singlet oxygen in water and… read more here.
Keywords: water; fullerene; photodynamic activity; pfd chl ... See more keywords
Synthesis, characterization, photodynamic activity of half-sandwich rhodium(III) complexes with curcuminoids.
Sign Up to like & getrecommendations! Published in 2020 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2020.102049
Abstract: Half-sandwich Cp*-Rh complexes containing curcuminoids ([Rh(η5-Cp*)(L)(Py)]PF6, 1-3, L = curcuminoid ligands L1-L3) were prepared, characterized and studied for anticancer activity. Complex 1 was structurally characterized by single-crystal X-ray crystallography. Complex 3 presented excellent photodynamic anticancer effect in… read more here.
Keywords: photodynamic activity; characterization photodynamic; half; half sandwich ... See more keywords
"On-Demand" Antimicrobial Photodynamic Activity through Supramolecular Photosensitizers Built with Rose Bengal and (p-Vinylbenzyl)triethylammomium Polycation Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00596
Abstract: The antimicrobial photodynamic activity (aPDA) in fungal and bacterial strains of supramolecular adducts formed between the anionic photosensitizer (PS) Rose Bengal (RB2-) and aromatic polycations derived from (p-vinylbenzyl)triethylammonium chloride was evaluated. Stable supramolecular adducts with… read more here.
Keywords: antimicrobial photodynamic; polycation; rose bengal; chemistry ... See more keywords
Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01584
Abstract: Because cancer is the second leading cause of death globally, investigation of new photosensitizers for photodynamic therapy is highly desirable. In this work, different peripherally substituted subphthalocyanines (SubPcs) with either a benzocrown moiety (CE-) or… read more here.
Keywords: photodynamic activity; subphthalocyanines efficient; cancer; photosensitizers nanomolar ... See more keywords
Improvement of Photodynamic Activity by a Stable System Consisting of a C60 Derivative and Photoantenna in Liposomes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00691
Abstract: A dyad system comprising a lipid membrane-incorporated fullerene derivative with an N,N-dimethylpyrrodinium group (C60-1) and a photoantenna molecule (DiD) did not exhibit the high photodynamic activity expected based on its singlet oxygen generation ability. Comparison… read more here.
Keywords: system; fullerene derivative; photodynamic activity; improvement photodynamic ... See more keywords
A comparative study of the photophysicochemical and photodynamic activity properties of meso-4-methylthiophenyl functionalized Sn(IV) tetraarylporphyrins and triarylcorroles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424620500273
Abstract: Tin(IV) complexes of a 4-methylthiophenyl functionalized porphyrin (1-Sn) and its corrole analogue (2-Sn) were synthesized so that their photophysicochemical properties and photodynamic activities ... read more here.
Keywords: comparative study; photophysicochemical photodynamic; photodynamic activity; methylthiophenyl functionalized ... See more keywords
Novel Short PEG Chain-Substituted Porphyrins: Synthesis, Photochemistry, and In Vitro Photodynamic Activity against Cancer Cells
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DOI: 10.3390/ijms231710029
Abstract: This work presents the synthesis and characterization of metal-free, zinc (II), and cobalt (II) porphyrins substituted with short PEG chains. The synthesized compounds were characterized by UV-Vis, 1H and 13C NMR spectroscopy, and MALDI-TOF mass… read more here.
Keywords: photodynamic activity; activity; tested compounds; short peg ... See more keywords