NIR/ROS‐Responsive Black Phosphorus QD Vesicles as Immunoadjuvant Carrier for Specific Cancer Photodynamic Immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201905758
Abstract: 2D black phosphorus (BP) nanosheets and BP quantum dots (BPQD), as two main material styles of BP, are widely used in the biomedical filed. However, few stimuli‐responsive BP nanocarriers are reported to meet the need… read more here.
Keywords: bpnvs; nir ros; photodynamic immunotherapy; immunotherapy ... See more keywords
Self‐Sacrificially Degradable Pseudo‐Semiconducting Polymer Nanoparticles that Integrate NIR‐II Fluorescence Bioimaging, Photodynamic Immunotherapy, and Photo‐Activated Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203820
Abstract: Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, their clinical application is still hampered by their poor biodegradability. Herein, a self‐sacrificially biodegradable pseudo‐semiconducting polymer (PSP) for NIR‐II… read more here.
Keywords: self sacrificially; nir fluorescence; photodynamic immunotherapy; psp ... See more keywords
Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205694
Abstract: Photodynamic therapy (PDT) can generate reactive oxygen species (ROS) to cause cell apoptosis and induce immunogenic cell death (ICD) to activate immune response, becoming a promising antitumor modality. However, the overexpressions of indoleamine 2,3-dioxygenase (IDO)… read more here.
Keywords: self delivery; tumor; photodynamic immunotherapy; immune activation ... See more keywords
Three-in-One Oncolytic Adenovirus System Initiates a Synergetic Photodynamic Immunotherapy in Immune-Suppressive Cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207668
Abstract: Although photodynamic immunotherapy has been promoted in the clinical practice of cholangiocarcinoma, the insensitivity to photodynamic immunotherapy remains to be a great problem. This can be largely attributed to an immune-suppressive tumor microenvironment (TME) manifested… read more here.
Keywords: three one; immunotherapy; cholangiocarcinoma; photodynamic immunotherapy ... See more keywords
Chlorin e6 and CRISPR-Cas9 dual-loading system with deep penetration for a synergistic tumoral photodynamic-immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120194
Abstract: Photodynamic therapy (PDT) is a relatively safe and clinically promising treatment to combat primary tumors, especially epidermal carcinoma, while has negligible effects on distant metastasis. Therefore, this work reports a multifunctional nanosystem (HPR@CCP) exerting a… read more here.
Keywords: system; immunotherapy; penetration; crispr cas9 ... See more keywords
Biosynthetic Dendritic Cell-Exocytosed Aggregation-Induced Emission Nanoparticles for Synergistic Photodynamic Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c03597
Abstract: Dendritic cell (DC)-derived small extracellular vesicles (DEVs) are recognized as a highly promising alternative to DC vaccines; however, the clinical testing of DEV-based immunotherapy has shown limited therapeutic efficacy. Herein, we develop a straightforward strategy… read more here.
Keywords: cell; photodynamic immunotherapy; synergistic photodynamic; aggregation induced ... See more keywords
Engineering a photosensitizer nanoplatform for amplified photodynamic immunotherapy via tumor microenvironment modulation.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale horizons"
DOI: 10.1039/d0nh00480d
Abstract: Photosensitizer-based photodynamic therapy (PDT) can not only kill tumor cells by the generated cytotoxic reactive oxygen species (ROS), but also trigger immunogenic cell death (ICD) and activate an immune response for immunotherapy. However, such photodynamic… read more here.
Keywords: tumor microenvironment; photosensitizer; photodynamic immunotherapy; tumor ... See more keywords
A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01291j
Abstract: Due to the complex bloodstream components, tumor microenvironment and tumor heterogeneity, traditional nanoparticles have a limited effect (low drug delivery efficiency and poor penetration to the deeper tumor) on eradicating tumors. To solve these challenges,… read more here.
Keywords: immunotherapy; responsive biomimetic; photodynamic immunotherapy; chemo photodynamic ... See more keywords
A mitochondria-localized iridium(iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc06675k
Abstract: Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor through the localized generation of reactive oxygen species, while metastatic tumors remain poorly affected. Complementary immunotherapy is effective in eliminating small, non-localized tumors… read more here.
Keywords: two photon; photon photodynamic; melanoma; immunotherapy ... See more keywords
Multifunctional Nanosystems Powered Photodynamic Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.905078
Abstract: Photodynamic Therapy (PDT) with the intrinsic advantages including non-invasiveness, spatiotemporal selectivity, low side-effects, and immune activation ability has been clinically approved for the treatment of head and neck cancer, esophageal cancer, pancreatic cancer, prostate cancer,… read more here.
Keywords: multifunctional nanosystems; photodynamic immunotherapy; powered photodynamic; nanosystems powered ... See more keywords
Insight into the Prospects for Tumor Therapy Based on Photodynamic Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111359
Abstract: Malignancy is one of the common diseases with high mortality worldwide and the most important obstacle to improving the overall life expectancy of the population in the 21st century. Currently, single or combined treatments, including… read more here.
Keywords: immune responses; photodynamic immunotherapy; therapy; tumor ... See more keywords