Photoinduced Vicinal 1,2-Difunctionalization of Olefins for the Synthesis of Alkyl Sulfonamides.
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DOI: 10.1021/acs.orglett.3c00182
Abstract: Alkyl sulfonamides are an important class of bioactive molecules. Historical syntheses have relied on multistep sequences incorporating harsh reaction conditions. Photochemical methods have been limited to hydrosulfamoylation, installing only one substituent across an olefin. Herein,… read more here.
Keywords: alkyl sulfonamides; vicinal difunctionalization; photoinduced vicinal; difunctionalization olefins ... See more keywords
Photoinduced Vicinal Sulfamoyloximation of Alkenes: Harnessing Bifunctional Nitrosamines via a Rapid Radical Trapping Strategy.
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DOI: 10.1021/acs.orglett.4c02245
Abstract: We developed a photoinduced method for vicinal sulfamoyloximation of alkenes using N-nitrosamines as bifunctional reagents, with DABSO serving as both a sulfonyl source and a rapid aminyl radical trap. This strategy prevents radical recombination, enabling… read more here.
Keywords: alkenes harnessing; vicinal sulfamoyloximation; sulfamoyloximation alkenes; strategy ... See more keywords