Optofluidic neural interfaces for in vivo photopharmacology.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2022.102195
Abstract: Light-sensitive small molecules can be applied to control cell signaling with enhanced spatiotemporal precision, and their accuracy in intact tissues like the brain can be further enhanced by tethering them to genetically encoded protein tags.… read more here.
Keywords: neural interfaces; optofluidic neural; interfaces vivo; vivo photopharmacology ... See more keywords
Reversible Regulation of Succinate Dehydrogenase by Tools of Photopharmacology.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08198
Abstract: Succinate dehydrogenase (SDH) is extremely important in metabolic function and biological processes. Modulation of SDH has been reported to be a promising therapeutic target to SDH mutations. Current measures for the regulation of SDH are… read more here.
Keywords: dehydrogenase; photopharmacology; regulation; succinate dehydrogenase ... See more keywords
Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c11336
Abstract: Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision. This is achieved through incorporation of molecular photoswitches and photocages into the pharmacophore.… read more here.
Keywords: insight; transporter homologue; photopharmacology; glutamate transporter ... See more keywords
Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11422
Abstract: Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which bodes well for… read more here.
Keywords: gpcr; antagonist toolbox; real time; photopharmacology ... See more keywords