Mesenchymal Stem Cells With Pharmacological Combinations Necessary to Maximize Retinal Photoreceptor, Outer and Inner Nuclear Layers Rescue.
Sign Up to like & getrecommendations! Published in 2025 at "Cell biology international"
DOI: 10.1002/cbin.70106
Abstract: The rising prevalence of retinal diseases underscores the need for personalized neuroprotection strategies. Mesenchymal stem cells (MSCs) exhibit paracrine neuroprotective potential and are used clinically when transplantation is unnecessary. This study evaluated MSC‐mediated photoreceptor rescue… read more here.
Keywords: mesenchymal stem; inner nuclear; stem cells; vip nic ... See more keywords
The MicroRNA, miR‐18a, Regulates NeuroD and Photoreceptor Differentiation in the Retina of Zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22666
Abstract: During embryonic retinal development, six types of retinal neurons are generated from multipotent progenitors in a strict spatiotemporal pattern. This pattern requires cell cycle exit (i.e. neurogenesis) and differentiation to be precisely regulated in a… read more here.
Keywords: photoreceptor differentiation; 18a regulates; photoreceptor; regulates neurod ... See more keywords
Retinoic acid and taurine enhance differentiation of the human bone marrow stem cells into cone photoreceptor cells and retinal ganglion cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30151
Abstract: Degeneration and apoptotic death of the photoreceptor cell-layer of retina are a major cause of irreversible blindness in the development era. The stem cell replacement therapy is one of the strategies for the retinal repairing.… read more here.
Keywords: photoreceptor; stem; cell; taurine ... See more keywords
Alterations of Lipidomes in Rat Photoreceptor Degeneration Induced by N-Methyl-N-nitrosourea.
Sign Up to like & getrecommendations! Published in 2021 at "Lipids"
DOI: 10.1002/lipd.12306
Abstract: To investigate alterations of lipidomes in the progress of photoreceptor degeneration induced by N-methyl-N-nitrosourea (MNU) in a rat model, retinal lipid molecular species in adult Sprague-Dawley (SD) rats at 1, 3, and 7 days after MNU… read more here.
Keywords: photoreceptor degeneration; induced methyl; degeneration induced; photoreceptor ... See more keywords
Capturing the photo‐signaling state of a photoreceptor in a steady‐state fashion by binding a transition metal complex
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3284
Abstract: Binding a small molecule to proteins causes conformational changes, but often to a limited extent. Here, we demonstrate that the interaction of a CO‐releasing molecule (CORM3) with a photoreceptor photoactive yellow protein (PYP) drives large… read more here.
Keywords: state; protein; signaling state; photoreceptor ... See more keywords
Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_40
Abstract: Humans with mutations in the phototransduction pathway develop forms of retinal degeneration, such as retinitis pigmentosa, cone dystrophy, or Leber congenital amaurosis. Similarly, numerous phototransduction mutant animal models resemble retinal degeneration. In our lab, using… read more here.
Keywords: photoreceptor degeneration; speed photoreceptor; photoreceptor; cgmp levels ... See more keywords
PKG-Dependent Cell Death in 661W Cone Photoreceptor-like Cell Cultures (Experimental Study).
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_63
Abstract: In humans cone photoreceptors are responsible for high-resolution colour vision. A variety of retinal diseases can compromise cone viability, and, at present, no satisfactory treatment options are available. Here, we present data towards establishing a… read more here.
Keywords: photoreceptor; study; cell death; cone ... See more keywords
Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss
Sign Up to like & getrecommendations! Published in 2024 at "GeroScience"
DOI: 10.1007/s11357-024-01362-2
Abstract: Age-related macular degeneration (AMD) is a leading cause of blindness in elderly populations, yet the molecular events that initiate the early retinal defects that lead to visual function deficits remain poorly understood. The studies here… read more here.
Keywords: mice; stress; response; redd1 mice ... See more keywords
Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02783-w
Abstract: In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller glia to function as stem cells, producing progenitors that regenerate photoreceptors. MicroRNAs (miRNAs) regulate CNS neurogenesis, but the roles… read more here.
Keywords: photoreceptor regeneration; mir 18a; mir 18ami5012; photoreceptor ... See more keywords
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.02.006
Abstract: Cancer cells often express differentiation programs unrelated to their tissue of origin, although the contribution of these aberrant phenotypes to malignancy is poorly understood. An aggressive subgroup of medulloblastoma, a malignant pediatric brain tumor of… read more here.
Keywords: subgroup; crx define; nrl crx; photoreceptor ... See more keywords
Photoreceptor calcium sensor proteins in detergent-resistant membrane rafts are regulated via binding to caveolin-1.
Sign Up to like & getrecommendations! Published in 2018 at "Cell calcium"
DOI: 10.1016/j.ceca.2018.04.003
Abstract: Rod cell membranes contain cholesterol-rich detergent-resistant membrane (DRM) rafts, which accumulate visual cascade proteins as well as proteins involved in regulation of phototransduction such as rhodopsin kinase and guanylate cyclases. Caveolin-1 is the major integral… read more here.
Keywords: resistant membrane; photoreceptor; caveolin; calcium ... See more keywords