Inhibition of GSK-3β Activation Protects SD Rat Retina Against N-Methyl-N-Nitrosourea-Induced Degeneration by Modulating the Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0973-2
Abstract: Retinal degenerative diseases are characterized by photoreceptor cell loss. Photoreceptor cell loss leading to retinal degeneration can be induced by N-methyl-N-nitrosourea (MNU), which was widely used to mimic the pathology. However, the mechanism by which… read more here.
Keywords: photoreceptor cell; degeneration; gsk; cell loss ... See more keywords
Lysergic acid diethylamide causes photoreceptor cell damage through inducing inflammatory response and oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2018.1423620
Abstract: Abstract Lysergic acid diethylamide (LSD), a classical hallucinogen, was used as a popular and notorious substance of abuse in various parts of the world. Its abuse could result in long-lasting abnormalities in retina and little… read more here.
Keywords: photoreceptor cell; photoreceptor; acid diethylamide; lysergic acid ... See more keywords
Rhodopsin signaling mediates light-induced photoreceptor cell death in rd10 mice through a transducin-independent mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz299
Abstract: Retinitis pigmentosa (RP) is a debilitating blinding disease affecting over 1.5 million people worldwide, but the mechanisms underlying this disease are not well understood. One of the common models used to study RP is the… read more here.
Keywords: rd10 mice; photoreceptor cell; cell death;
Drosophila R8 photoreceptor cell subtype specification requires hibris
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240451
Abstract: Cell differentiation and cell fate determination in sensory systems are essential for stimulus discrimination and coding of environmental stimuli. Color vision is based on the differential color sensitivity of retinal photoreceptors, however the developmental programs… read more here.
Keywords: photoreceptor cell; photoreceptor; color sensitivity; cell ... See more keywords
Decitabine improves MMS-induced retinal photoreceptor cell damage by targeting DNMT3A and DNMT3B
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1057365
Abstract: Introduction Retinitis pigmentosa (RP) is a group of neurodegenerative retinopathies causing blindness due to progressive and irreversible photoreceptor cell death. The alkylating agent methyl methanesulfonate (MMS) can induce selective photoreceptor cell death, which is used… read more here.
Keywords: cell damage; mms induced; damage; photoreceptor ... See more keywords
Inhibition of the MAPK/c-Jun-EGR1 Pathway Decreases Photoreceptor Cell Death in the rd1 Mouse Model for Inherited Retinal Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314600
Abstract: Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies that typically results in photoreceptor cell death and vision loss. Here, we explored the effect of early growth response-1 (EGR1) expression on photoreceptor cell death… read more here.
Keywords: cell death; expression; photoreceptor cell;
Topical Ocular Administration of Progesterone Decreases Photoreceptor Cell Death in Retinal Degeneration Slow (rds) Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030328
Abstract: Retinitis pigmentosa (RP) is an inherited eye disorder which triggers a cascade of retinal disorders leading to photoreceptor cell death and for which there is currently no effective treatment. The purpose of this research was… read more here.
Keywords: cell death; eye; rds mice; photoreceptor cell ... See more keywords