A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24631
Abstract: Background: Opsins are a group of lightâsensitive proteins present in photoreceptor cells, which convert the energy of photons into electrochemical signals, thus allowing vision. Given their relevance, we aimed to visualize the two red opsins… read more here.
Keywords: opsin; photoreceptor cells; outer segments; line ... See more keywords
Presence of calpain-5 in mitochondria.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.144
Abstract: Calpains are Ca2+-dependent cysteine proteases that are widely distributed in animal tissues and modulate a variety of cellular processes. There are 15 members of the calpain family in mammals. In animal cells, there are three… read more here.
Keywords: calpain; photoreceptor cells; microscopy; calpain mitochondria ... See more keywords
Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20893-1
Abstract: Retinal guanylate cyclase (RetGC) and guanylate cyclase activating proteins (GCAPs) play an important role during the light response in photoreceptor cells. Mutations in these proteins are linked to distinct forms of blindness. RetGC and GCAPs… read more here.
Keywords: cyclase activating; photoreceptor cells; guanylate cyclase; retgc ... See more keywords
Visual Responses of Photoreceptor-Degenerated Rats Expressing Two Different Types of Channelrhodopsin Genes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41210
Abstract: Optogenetic technologies are expected to be applicable for clinical use in restoring vision. However, the degree of recovered visual function is highly dependent on the function of the chosen optogenetic gene. To investigate the effect… read more here.
Keywords: transgenic rats; photoreceptor cells; photoreceptor; native photoreceptor ... See more keywords
Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43062
Abstract: Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations in many spliceosome genes confer human eye diseases. Mutations in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose… read more here.
Keywords: photoreceptor cells; crispr cas9; photoreceptor; rp9 ... See more keywords
Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.667959
Abstract: Background: Retinal photoreceptor (RP) cells are widely involved in retina-related diseases, and oxidative stress plays a critical role in retinal secondary damage. Herein, we investigated the effectiveness and potential mechanisms of autophagy of paeonol (Pae)… read more here.
Keywords: retinal photoreceptor; photoreceptor cells; pae; paeonol induces ... See more keywords
Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158156
Abstract: Interleukin-27 is constitutively secreted by microglia in the retina or brain, and upregulation of IL-27 during neuroinflammation suppresses encephalomyelitis and autoimmune uveitis. However, while IL-35 is structurally and functionally similar to IL-27, the intrinsic roles… read more here.
Keywords: cells constitutively; immune privilege; photoreceptor cells; photoreceptor ... See more keywords
Proteomic Profiling Revealed Mitochondrial Dysfunction in Photoreceptor Cells under Hyperglycemia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113366
Abstract: Diabetic retinopathy (DR) was identified as a leading cause of blindness and vision impairment in 2020. In addition to vasculopathy, DR has been found to involve retinal neurons, including amacrine cells and retinal ganglion cells.… read more here.
Keywords: proteomic profiling; mitochondrial dysfunction; high glucose; photoreceptor cells ... See more keywords
Study of the Antioxidative Effects of Bombyx mori Silk Sericin in Cultures of Murine Retinal Photoreceptor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144635
Abstract: The availability of natural substances able to fulfill the role of antioxidants in a physiologic environment is important for the development of therapies against diseases associated with excessive production of reactive oxygen species and ensuing… read more here.
Keywords: cultures murine; sericin; retinal photoreceptor; bombyx mori ... See more keywords
Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells
Sign Up to like & getrecommendations! Published in 2023 at "Proteomes"
DOI: 10.3390/proteomes11020012
Abstract: Photoreceptor cells are highly susceptible to oxidative-stress-induced damage due to their high metabolic rate. Oxidative stress plays a key role in driving pathological events in several different ocular diseases, which lead to retinal degeneration and… read more here.
Keywords: stress; oxidative stress; stress induced; dysfunction ... See more keywords