Alterations of Lipidomes in Rat Photoreceptor Degeneration Induced by N-Methyl-N-nitrosourea.
Sign Up to like & getrecommendations! Published in 2021 at "Lipids"
DOI: 10.1002/lipd.12306
Abstract: To investigate alterations of lipidomes in the progress of photoreceptor degeneration induced by N-methyl-N-nitrosourea (MNU) in a rat model, retinal lipid molecular species in adult Sprague-Dawley (SD) rats at 1, 3, and 7 days after MNU… read more here.
Keywords: photoreceptor degeneration; induced methyl; degeneration induced; photoreceptor ... See more keywords
Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_40
Abstract: Humans with mutations in the phototransduction pathway develop forms of retinal degeneration, such as retinitis pigmentosa, cone dystrophy, or Leber congenital amaurosis. Similarly, numerous phototransduction mutant animal models resemble retinal degeneration. In our lab, using… read more here.
Keywords: photoreceptor degeneration; speed photoreceptor; photoreceptor; cgmp levels ... See more keywords
Optical coherence tomography biomarkers of photoreceptor degeneration in retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2021 at "International Ophthalmology"
DOI: 10.1007/s10792-021-01964-1
Abstract: Several parameters on optical coherence tomography (OCT) have been suggested as biomarkers for photoreceptor degeneration in retinitis pigmentosa (RP). This study is to compare the spatial distribution of the changes of OCT biomarkers in RP… read more here.
Keywords: photoreceptor degeneration; roi; biomarkers photoreceptor; retinitis pigmentosa ... See more keywords
The pigmented epithelium, a bright partner against photoreceptor degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2017.1395876
Abstract: Abstract Sight depends on the intimate association between photoreceptors and pigment epithelial cells. The evolutionary origin of this cellular tandem can be traced back to the emergence of bilateral animals, at least 450 million years… read more here.
Keywords: pigmented epithelium; bright partner; photoreceptor degeneration; epithelium bright ... See more keywords
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade9459
Abstract: Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models of Mertk ablation… read more here.
Keywords: inflammation; mertk; degeneration; early onset ... See more keywords
Photoreceptor degeneration in ABCA4-associated retinopathy and its genetic correlates
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155373
Abstract: BACKGROUND Outcome measures sensitive to disease progression are needed for ATP-binding cassette, sub-family A, member 4–associated (ABCA4-associated) retinopathy. We aimed to quantify ellipsoid zone (EZ) loss and photoreceptor degeneration beyond EZ-loss in ABCA4-associated retinopathy and… read more here.
Keywords: abca4 associated; loss; photoreceptor degeneration; associated retinopathy ... See more keywords
Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye.
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical optics express"
DOI: 10.1364/boe.10.000066
Abstract: Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe… read more here.
Keywords: photoreceptor degeneration; induced photoreceptor; cellular scale; degeneration ... See more keywords
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s194169
Abstract: Objective Retinitis pigmentosa causes progressive photoreceptor degeneration in the subjects while no clinical therapy exists. The present study sought to evaluate the potential protective effects of taurine on a pharmacologically induced RP animal model. Methods… read more here.
Keywords: photoreceptor degeneration; taurine treatment;
Astragaloside A Protects Against Photoreceptor Degeneration in Part Through Suppressing Oxidative Stress and DNA Damage-Induced Necroptosis and Inflammation in the Retina
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s362401
Abstract: Purpose Photoreceptors are specialized retinal neurons responsible for phototransduction. Loss of photoreceptors directly leads to irreversible vision impairment. Pharmacological therapies protecting against photoreceptor degeneration are clinically lacking. Oxidative stress and inflammation are common mechanisms playing… read more here.
Keywords: photoreceptor degeneration; bright light; oxidative stress; degeneration ... See more keywords
Corrigendum: Large-Area Photoreceptor Degeneration Model in Rabbits by Photocoagulation and Oxidative Stress in the Retina
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.738004
Abstract: [This corrects the article DOI: 10.3389/fnins.2021.617175.]. read more here.
Keywords: corrigendum large; photoreceptor degeneration; model rabbits; degeneration model ... See more keywords
Ginkgo biloba Extract Attenuates Light-Induced Photoreceptor Degeneration by Modulating CAV-1—Redoxosome Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11071268
Abstract: The clinical potential of Ginkgo biloba extract (GBE) in the prevention and/or treatment of retinal degenerative diseases has been widely explored; however, the underlying molecular mechanism is poorly understood. Photoreceptor degeneration is the hallmark of… read more here.
Keywords: effect; photoreceptor degeneration; illumination; photoreceptor ... See more keywords