CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx137
Abstract: In humans, CERKL mutations cause widespread retinal degeneration: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressively, death of cells in the inner retina. Despite intensive efforts, the function… read more here.
Keywords: phagocytosis; dystrophy; photoreceptor outer; rod cone ... See more keywords
PRCD is Concentrated at the Base of Photoreceptor Outer Segments and is Involved in Outer Segment Disc Formation.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz248
Abstract: Mutations of the PRCD gene are associated with rod-cone degeneration in both dogs and humans. Prcd is expressed in the mouse eye as early as embryonic day 14. In the adult mouse retina PRCD is… read more here.
Keywords: photoreceptor outer; segment; outer segment; microscopy ... See more keywords
PHOTORECEPTOR OUTER SEGMENT IS EXPANDED IN THE FELLOW EYE OF PATIENTS WITH UNILATERAL CENTRAL SEROUS CHORIORETINOPATHY.
Sign Up to like & getrecommendations! Published in 2020 at "Retina"
DOI: 10.1097/iae.0000000000002846
Abstract: PURPOSE To quantitatively evaluate the photoreceptor structural changes in the fellow unaffected eyes of patients with unilateral central serous chorioretinopathy (CSC). METHODS This is a retrospective cross-sectional study. We analyzed data from patients with diagnosis… read more here.
Keywords: photoreceptor outer; csc; photoreceptor; outer segment ... See more keywords
Electron Microscopic Evidence of Photoreceptor Outer-segments in the Trabecular Meshwork in a Case of Schwartz-Matsuo Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000001311
Abstract: Purpose: To describe a case of photoreceptor outer segment glaucoma (Schwartz-Matsuo syndrome) with electron microscopic evidence of photoreceptor outer segments in the trabecular meshwork (TM). Design: This is a clinicopathologic case report. Participant: A 48-year-old… read more here.
Keywords: outer segments; photoreceptor outer; schwartz matsuo; matsuo syndrome ... See more keywords
Clinical relevance of fibrin membranous structures in the intra‐photoreceptor outer segment separation on spectral domain optical coherence tomography (SD‐OCT) in initial‐onset acute Vogt‐Koyanagi‐Harada disease
Sign Up to like & getrecommendations! Published in 2022 at "Acta Ophthalmologica"
DOI: 10.1111/aos.15268
Abstract: The purpose of the study was to investigate clinical relevance of fibrin membranous structure (FMS) in the photoreceptor outer segments on spectral‐domain optical coherence tomography (SD‐OCT) in untreated initial‐onset acute Vogt‐Koyanagi‐Harada (VKH) disease. read more here.
Keywords: domain optical; clinical relevance; photoreceptor outer; spectral domain ... See more keywords
Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases
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DOI: 10.1371/journal.pone.0237078
Abstract: Purpose To investigate the association between outer retinal layer metrics, including photoreceptor outer segment volume, on spectral-domain optical coherence tomography (OCT) and brain volume on MRI in normal aging, Alzheimer’s disease and Parkinson’s disease. Methods… read more here.
Keywords: volume; correlation; photoreceptor outer; brain volume ... See more keywords
TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21228677
Abstract: Photoreceptor disc component (PRCD) is a small protein which is exclusively localized to photoreceptor outer segments, and is involved in the formation of photoreceptor outer segment discs. Mutations in PRCD are associated with retinal degeneration… read more here.
Keywords: tulp1 tub; photoreceptor; photoreceptor outer; outer ... See more keywords
Transient Retention of Photoreceptor Outer Segments in Matrigel-Embedded Retinal Organoids
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314893
Abstract: Retinal organoids (ROs) are three-dimensional retinal tissues, which are differentiated in vitro from induced pluripotent stem cells (iPSC), ultimately forming all main retinal cell types under defined culture conditions. ROs show several highly specialized retinal… read more here.
Keywords: culture; outer segments; photoreceptor outer; retinal organoids ... See more keywords