Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231912033
Abstract: Mutations in C8orf37 cause Bardet-Biedl syndrome (BBS), retinitis pigmentosa (RP), and cone–rod dystrophy (CRD), all manifest in photoreceptor degeneration. Little is known about which proteins C8orf37 interacts with to contribute to photoreceptor survival. To determine… read more here.
Keywords: c8orf37 fam161a; interactions c8orf37; photoreceptor survival; fam161a two ... See more keywords
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.83205
Abstract: Ciliopathies manifest from sensory abnormalities to syndromic disorders with multiorgan pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To identify drug candidates… read more here.
Keywords: reserpine; reserpine maintains; rd16 mouse; photoreceptor survival ... See more keywords