Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis.
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DOI: 10.1021/acs.orglett.0c02008
Abstract: The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer… read more here.
Keywords: remote sp3; copper; cyanation; sp3 cyanation ... See more keywords
Photoredox/Copper Dual-Catalyzed Benzylic C-H Esterification via Radical-Polar Crossover.
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DOI: 10.1021/acs.orglett.2c00763
Abstract: Herein, we report a distinctive photoredox/copper dual-catalyzed esterification of benzylic C-H bonds through the combination of photoredox-mediated hydrogen atom transfer and Cu(II)-mediated radical-polar crossover. This methodology demonstrates a high functional group tolerance (>40 examples) and… read more here.
Keywords: polar crossover; dual catalyzed; copper dual; photoredox copper ... See more keywords
Synthesis of α-Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis.
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DOI: 10.1021/acs.orglett.2c00969
Abstract: The development of mild and practical conditions for the fluoroalkylation of arenes is an ongoing challenge in chemical organic synthesis. Herein, we report a metallaphotoredox method for the preparation of fluoroalkyl arenes based on the… read more here.
Keywords: catalysis; synthesis fluorinated; dual catalysis; copper dual ... See more keywords
Radical Multicomponent Alkyl Alkynylation of Propellane via Synergistic Photoredox and Copper Catalysis.
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DOI: 10.1021/acs.orglett.2c01721
Abstract: Bicyclo[1.1.1]pentanes (BCPs) are important bioisosteres of aryl, tert-butyl groups, and internal alkynes that can impact key physicochemical properties on drug candidates. Herein, we describe a novel and efficient reaction to synthesize alkyl-alkynyl-substituted BCP derivatives by… read more here.
Keywords: synergistic photoredox; photoredox copper; copper catalysis; alkyl ... See more keywords
Selective Three-Component 1,2-Aminoalkoxylation of 1-Aryl-1,3-dienes by Dual Photoredox and Copper Catalysis.
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DOI: 10.1021/acs.orglett.2c03124
Abstract: A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This protocol uses N-aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to… read more here.
Keywords: dual photoredox; three component; dienes dual; photoredox copper ... See more keywords
Photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN: access to antifungal active tetrasubstituted pyrazines.
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DOI: 10.1039/d2cc02480b
Abstract: A photoredox/copper cocatalyzed domino cyclization of oxime esters with TMSCN has been developed. A range of structurally novel tetrasubstituted pyrazines have been obtained. This method features high bond-forming efficiency, high step economy, broad substrate scope,… read more here.
Keywords: oxime esters; domino cyclization; cocatalyzed domino; copper cocatalyzed ... See more keywords
Open-air green-light-driven ATRP enabled by dual photoredox/copper catalysis
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DOI: 10.1039/d2sc04210j
Abstract: Photoinduced atom transfer radical polymerization (photo-ATRP) has risen to the forefront of modern polymer chemistry as a powerful tool giving access to well-defined materials with complex architecture. However, most photo-ATRP systems can only generate radicals… read more here.
Keywords: photoredox; dual photoredox; photoredox copper; copper catalysis ... See more keywords