Development of a Phototoxicity Testing Strategy for Accurate Photosafety Evaluation of Pharmaceuticals Based on the Assessment of Possible Melanin-Binding Effects
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DOI: 10.1177/1091581818777998
Abstract: Drug-induced phototoxicity occurs when drugs absorb natural sunlight, leading to chemical reactions causing cellular damage. Distribution to light-exposed tissues is critical and is enhanced by binding to melanin. The International Council on Harmonization S10 guidance… read more here.
Keywords: photosafety evaluation; evaluation pharmaceuticals; melanin; melanin binding ... See more keywords